Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agentic Designer: Progressive Multi-Agent Collaboration for Structure-Aware Interior Layout Generation.

IEEE transactions on pattern analysis and machine intelligence·2026
Same author

Effects of different resistance loads during resisted sprint running on internal stresses of the ankle joint: a finite element analysis.

Computer methods in biomechanics and biomedical engineering·2026
Same author

Effects of Pre-Competition Neuromuscular Electrical Stimulation Activation on Forward Lunge Performance and Neuromuscular Control in Squash Athletes: An Analysis Based on Timing and Electromyographic Sensors.

Sensors (Basel, Switzerland)·2026
Same author

Acquired HIV-1 Drug Resistance and Molecular Transmission Networks in Zhongwei, Ningxia, China.

Viruses·2026
Same author

HIV-1 molecular transmission networks among MSM in Ningxia, China (2018-2024): insights into local transmission dynamics and drug resistance.

Frontiers in microbiology·2026
Same author

Cyclist behavioral persistence across consecutive intersections: Re-ID based analysis and intention prediction.

Accident; analysis and prevention·2026

Related Experiment Video

Updated: May 23, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

779

Liquid Bridge Cutting Valves for Microfluidic Passive Distribution and Sequential Reaction.

Rongzan Lin1, Wen Guo1, Yuqiu Chen1

  • 1School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.

Small (Weinheim an Der Bergstrasse, Germany)
|March 10, 2025
PubMed
Summary

New liquid bridge cutting valves (LBCVs) enable automatic liquid segregation in microfluidics. This innovation prevents crosstalk and allows for precise sequential reactions in wearable devices and lab-on-a-chip applications.

Keywords:
lab‐on‐a‐chipliquid bridge cutting valvesmicrofluidicspassive liquid isolation

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.0K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.3K

Related Experiment Videos

Last Updated: May 23, 2025

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology
07:03

Author Spotlight: Integrating Computational and Experimental Approaches in Precision Oncology

Published on: December 1, 2023

779
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.0K
Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices
10:18

Multi-step Variable Height Photolithography for Valved Multilayer Microfluidic Devices

Published on: January 27, 2017

14.3K

Area of Science:

  • Biotechnology
  • Microfluidics
  • Analytical Chemistry

Background:

  • Accurate bioanalysis requires precise liquid isolation to prevent crosstalk.
  • Existing microfluidic valves lack the capability for passive liquid isolation.

Purpose of the Study:

  • To introduce and characterize liquid bridge cutting valves (LBCVs) for automated liquid segregation in microfluidic systems.
  • To demonstrate the application of LBCVs in sequential reactions and real-time monitoring.

Main Methods:

  • Studied the principle of liquid bridge breakup to design LBCVs.
  • Developed monolithic chips with LBCVs in various configurations for fluid manipulation.
  • Integrated LBCVs for detecting sweat glucose, lactate, and cortisol via ELISA.

Main Results:

  • LBCVs successfully established airlocks for automatic liquid segregation.
  • Monolithic chips facilitated sequential sampling and reactions.
  • Demonstrated successful detection of biomarkers in wearable and lab-on-a-chip formats.

Conclusions:

  • LBCVs are a novel microfluidic element for precise liquid separation.
  • LBCVs enable complex fluid manipulation for healthcare monitoring and clinical applications.
  • This technology integrates seamlessly with existing microfluidic structures for advanced lab-on-a-chip devices.