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Updated: May 23, 2025

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
Published on: July 30, 2017
Palladium/Norbornene Cooperative Catalysis 2-Fold C-H/C-X Coupling: Construction of Polycyclic Aromatic Hydrocarbons
Ming-Xuan Wang1, Yi-Ming Li1, Wei Zeng2
1Key Laboratory of Molecular Pharmacology and Drug Evaluation, Ministry of Education, School of Pharmacy, Yantai University, Shandong, Yantai 264005, P. R. China.
Abstract:
A palladium/norbornene (NBE)-catalyzed 2-fold C-H/C-X coupling reaction of aryl iodides is reported. Bromine-substituted benzimidazoles were chosen as electrophilic and termination reagents, and the versatile polycyclic aromatic hydrocarbon products were successfully obtained. The strategy overcomes the challenge of catalyst poisoning by heterocyclic substrates. In addition, the imidazole moiety in the product is endowed with a localization role, thus enabling the compounds to be applied in a wider synthetic scenario, and the fluorescence persisted. Furthermore, the bioactivity evaluation has identified three promising leading compounds 3b, 4e, and 4i.
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