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Updated: May 23, 2025
Single-molecule Super-resolution Imaging of Phosphatidylinositol 4,5-bisphosphate in the Plasma Membrane with Novel Fluorescent Probes
Published on: October 15, 2016
ESIPT-driven imaging: a thiazole probe for lipid droplets and plasma membranes
José L Belmonte-Vázquez1, Juan L Cortes-Muñoz2, Adriana Romo-Pérez2
1Departamento de Química Orgánica - Facultad de Química (FQ), Universidad Nacional Autónoma de México (UNAM), Ciudad Universitaria, Ciudad de México 04510, Mexico.
Abstract:
Fluorescence imaging allows high-resolution visualization of cellular processes. This study introduces a novel ESIPT probe with dual localization for lipid droplets and plasma membranes. Initially, the blue channel imaging reveals the probe's affinity for the plasma membrane, and then it redistributes into lipid droplets, showcasing its strong affinity for the hydrophobic lipid core.
