Related Experiment Video

Updated: May 23, 2025

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
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Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

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Emerging Trends in Modulation of Transient Receptor Potential Canonical 6 Channels as Therapeutic Targets

Ayush Sharma1, Snehal Patel1, Mithun Singh Rajput1

  • 1Department of Pharmacology, Institute of Pharmacy, Nirma University, Ahmedabad, India.

Journal of Biochemical and Molecular Toxicology
|March 10, 2025
PubMed

Insights

Transient Receptor Potential Canonical 6 (TRPC6) channels regulate ion influx and are implicated in kidney disease and cancer. Modulating TRPC6 offers a promising therapeutic avenue for various TRPC6-related pathologies.

Area of Science:

  • Molecular Biology
  • Physiology
  • Pharmacology

Background:

  • Transient Receptor Potential Canonical 6 (TRPC6) is a nonselective cation channel involved in cellular signaling.
  • TRPC6 plays physiological roles in organs like the kidney, heart, and lungs.
  • Dysregulation of TRPC6 is linked to diseases such as focal segmental glomerulosclerosis and various cancers.

Purpose of the Study:

  • To review the multifaceted roles of TRPC6 channels in physiological and pathological conditions.
  • To summarize the Ca2+-dependent effects of TRPC6 in disease pathogenesis.
  • To highlight therapeutic strategies targeting TRPC6 modulators.

Main Methods:

  • Literature review of studies investigating TRPC6 function.
  • Analysis of research on TRPC6 mutations and expression patterns.
  • Examination of preclinical and clinical investigations of TRPC6 modulators.

Main Results:

  • TRPC6 is crucial in kidney podocytes, with mutations causing kidney disease.
  • TRPC6 overexpression is observed in cancers and chronic obstructive pulmonary disorder.
  • TRPC6 dysregulation contributes to cardiac hypertrophy.

Conclusions:

  • TRPC6 channel activity is vital in maintaining physiological functions.
  • Altering TRPC6 activity presents a potential therapeutic strategy for associated diseases.
  • Further research into TRPC6 modulators is warranted for disease prevention and treatment.
Keywords:
TRPC6activatorsinhibitorsion channelpathogenesis

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