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Association Between Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Abdominal Aortic Aneurysm: A
Da Lu1, Ke Si2, Guijun Huo3
1Department of Thoracic-Cardiac Surgery, Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, People's Republic of China.
Insights
The uric acid to high-density lipoprotein cholesterol ratio (UHR) is significantly higher in patients with abdominal aortic aneurysm (AAA). Elevated UHR is an independent risk factor, suggesting its utility in AAA screening.
Area of Science:
- Biomarkers
- Cardiovascular Research
- Inflammation Studies
Background:
- The uric acid to high-density lipoprotein cholesterol ratio (UHR) is a novel biomarker for inflammatory and anti-inflammatory interactions.
- The association between UHR and abdominal aortic aneurysm (AAA) risk remains unexplored.
Purpose of the Study:
- To investigate the potential role of UHR in predicting AAA.
- To determine if UHR is a significant risk factor for AAA development.
Main Methods:
- Retrospective analysis of 303 AAA patients and 408 controls.
- Logistic regression, Receiver Operating Characteristic (ROC) curves, and restricted cubic spline (RCS) analysis were used.
- Covariates were adjusted to evaluate the independent association between UHR and AAA.
Main Results:
- UHR levels were significantly higher in the AAA group compared to controls.
- UHR was identified as an independent risk factor for AAA, with a 12% increased risk per unit increase.
- ROC analysis yielded an area under the curve of 0.847, with an optimal cutoff of 17.2%.
- RCS analysis indicated a significant nonlinear relationship between UHR and AAA events (p < 0.001).
Conclusions:
- Elevated UHR levels are significantly associated with an increased risk of AAA.
- UHR can serve as a valuable indicator for dynamic screening and risk assessment of abdominal aortic aneurysm.
Objective:
Uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) has been recognized as a novel biomarker for evaluating inflammatory and anti-inflammatory interaction. However, it is not known whether UHR is related to abdominal aortic aneurysm (AAA). The current research aims to explore the potential role of UHR in predicting AAA.
Methods:
In this study, 303 AAA patients and 408 normal subjects were retrospectively analyzed. The relationship between UHR and AAA was evaluated using Logistic regression models. Receiver operating characteristic (ROC) curves and restricted cubic spline (RCS) analysis were employed to elucidate the detailed association between UHR and AAA.
Results:
UHR value in the AAA group was significantly higher than that in the normal group, and UHA was an independent risk factor for AAA. After adjusting for covariates, each 1-unit increase in UHR was associated with a 12% rise in AAA risk (OR: 1.12, 95% CI: 1.03, 1.21). ROC value of UHR was 0.847 (95% CI, 0.811~0.887, P < 0.05), and the optimal critical value of UHR was 17.2%. The incidence of AAA in the UHR≥17.2% group was significantly higher than that in the UHR < 17.2% group. RCS curves revealed a significant nonlinear relationship between UHR and AAA events (p-value < 0.001, p-nonlinear = 0.002).
Conclusion:
This study demonstrates that UHR levels are significantly linked to increased AAA risk, which can be widely used as an indicator for dynamic screening of AAA.
