Related Experiment Video
Updated: May 23, 2025
05:34
5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
432
RNA-Based Therapies in Kidney Diseases
Liang Hu1, Ting Jin2, Ning Zhang3
1Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, 321001, People's Republic of China.
Journal of Inflammation Research
|March 10, 2025
Summary
RNA therapeutics offer new hope for kidney disease treatment by targeting previously undruggable mechanisms. This review explores RNA-based strategies, including mRNA therapies, for advancing kidney disease care.
Area of Science:
- Biomedical Science
- Genetics
- Pharmacology
Background:
- Kidney diseases affect over 750 million people globally, with insufficient effective treatments.
- RNA therapeutics represent a rapidly advancing field with approved nucleic acid-based therapies.
- These therapies can target previously undruggable genes and proteins, expanding therapeutic options.
Purpose of the Study:
- To review RNA-based strategies for novel kidney disease treatments.
- To highlight the potential of mRNA-based therapies in this domain.
- To discuss the opportunities and challenges of applying these therapies to kidney diseases.
Main Methods:
- Review of current literature on RNA therapeutics.
- Analysis of antisense, RNA interference, mRNA-based, and CRISPR-Cas technologies.
- Discussion of therapeutic target identification and gene expression regulation.
Main Results:
- RNA therapeutics, particularly mRNA-based approaches, show significant promise for kidney disease treatment.
- These methods allow for precise targeting and regulation of disease-related molecules.
- Various RNA-based strategies are being developed to address unmet needs in nephrology.
Conclusions:
- RNA therapeutics offer a powerful new modality for treating kidney diseases.
- mRNA therapies present unique advantages in speed, flexibility, and targeting capabilities.
- Further research and development are needed to overcome challenges for widespread clinical application in kidney disease.
More Related Videos
07:01Delivery of Exogenous Artificially Synthesized miRNA Mimic to the Kidney Using Polyethylenimine Nanoparticles in Several Kidney Disease Mouse Models
Published on: May 10, 2022
1.5K
06:38A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
13.5K
Related Concept Videos
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
360
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
360
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:10Nephrons
2.0K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.0K
01:33Hormonal Regulation
32.8K
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
32.8K
01:45Kidney Structure
68.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
68.5K
00:59Gene Therapy
25.1K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
25.1K