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Structural Causes of Pattern Formation and Loss Through Model-Independent Bifurcation Analysis
Liam D O'Brien1, Adriana T Dawes1,2
1Department of Mathematics, The Ohio State University, 231 W 18th Ave, Columbus, 43210, Ohio, USA.
Research Square
|March 10, 2025
Summary
This study presents a new framework for understanding how cells form patterns. It reveals that intracellular signaling constraints lead to a single, stable cell fate pattern, aiding in network inference.
Area of Science:
- Developmental biology
- Systems biology
- Computational biology
Background:
- Precise cellular patterning is crucial for tissue and organ development.
- Conserved signaling networks regulate intracellular and intercellular communication.
- Previous work highlighted the role of intercellular communication in pattern formation.
Purpose of the Study:
- To develop a model-independent framework for analyzing pattern formation in homogeneous cell arrays.
- To investigate how intracellular signaling properties influence emergent patterns.
- To enable prediction of cell fate patterns with minimal assumptions.
Main Methods:
- Utilizing an ordinary differential equation (ODE) framework.
- Relying on general assumptions of global intercellular communication.
- Incorporating qualitative properties of local intracellular biochemical signaling.
Main Results:
- Demonstrated that constraints on local intracellular signaling lead to a single stable pattern.
- Showed this stable pattern is dependent on the qualitative features of the intracellular network.
- Established a framework that predicts cell fate patterns with minimal modeling assumptions.
Conclusions:
- The developed framework offers a powerful tool for inferring unknown signaling network interactions.
- Analysis of tissue-level patterns can elucidate underlying cellular communication mechanisms.
- This approach advances the understanding of developmental pattern formation.
Keywords:
24C1434A3434C2392C1592C4092C42bifurcation theorydevelopmental biologynetwork dynamicspattern formationsignaling networksMore Related Videos
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