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Published on: July 3, 2013
Quality of Life of Children with Idiopathic Nephrotic Syndrome
Jyoti Shukla1,2, Anita Gupta1, Raminder Kalra3
1Chitkara School of Health Sciences, Chitkara University, Punjab, India.
Insights
Children with nephrotic syndrome (NS) experience lower quality of life (QoL) than healthy peers, with school functioning most impacted. Recurrent relapses and treatments significantly impair their QoL.
Area of Science:
- Pediatric Nephrology
- Child Health Outcomes
- Quality of Life Research
Background:
- Nephrotic syndrome (NS) is a relapsing-remitting illness impacting children's formative years.
- It significantly affects children's physical and psychosocial well-being.
- Literature on quality of life (QoL) in pediatric NS is scarce.
Purpose of the Study:
- To discuss the QoL of children with NS.
- To identify factors influencing QoL in pediatric NS.
Main Methods:
- Systematic literature search (2004-2023) of PubMed, Google Scholar, and Embase.
- Included 19 original English articles evaluating QoL in children with NS.
- Excluded non-English articles, reviews, and studies on non-pediatric populations.
Main Results:
- Children with NS have lower QoL than healthy children (p<0.05) but better than those with other chronic diseases (p<0.001).
- School functioning was the most affected domain.
- Recurrent relapses, prolonged illness, high steroid dosages, and multiple medications impair QoL. Steroid-resistant nephrotic syndrome (SRNS) is associated with poorer QoL.
Conclusions:
- Children with NS face significant challenges impacting their QoL.
- Comprehensive care strategies are essential to enhance QoL in pediatric NS.
Background:
Nephrotic syndrome (NS) is relapsing-remitting illness affecting children and characterized by proteinuria, edema, and hypoalbuminemia. The disease involves the significant formative years of a child's life and profoundly impacts their physical and psychosocial well-being. There is a scarcity of literature exploring the quality of life (QoL) of children with NS and the factors influencing them. The study aimed to discuss the QoL of children with NS and the factors influencing it.
Materials And Methods:
A systematic search of electronic databases, including PubMed, Google Scholar, and Embase, was carried out from 2004 to August 2023. Nineteen original articles in English language that focused on evaluating the QoL of children with NS were included. Articles in languages other than English, letters, and editorial reviews, studies involving populations other than children, were excluded.
Results:
Children with NS tend to have a better QoL as compared to those with other chronic diseases (p = <0.001), but it remains lower than that of healthy children (p<0.05). School functioning was the most affected domain. Recurrent relapses, prolonged illness, high steroid dosages, and multiple medications are significant contributors to impaired QoL. Children with steroid-resistant nephrotic syndrome (SRNS) had poorer QoL among the clinical subtypes.
Conclusion:
Children with NS face various challenges that impact their QoL. Comprehensive care strategies to enhance QoL are the need of the hour.
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