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Updated: May 23, 2025
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Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
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Colorectal Cancer: Pathogenesis and Targeted Therapy
Jingyuan Li1,2, Jiashu Pan1,2, Lisheng Wang3,4
1Institute of Digestive Diseases China-Canada Center of Research for Digestive Diseases Longhua Hospital Shanghai University of Traditional Chinese Medicine Shanghai China.
Medcomm
|March 10, 2025
Summary
Colorectal cancer (CRC) involves genetic and epigenetic changes impacting tumor metabolism. Understanding this interplay offers new therapeutic strategies for CRC treatment.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Epigenetics
Background:
- Colorectal cancer (CRC) is a leading global malignancy.
- Genetic alterations and epigenetic dysregulation are key in CRC pathogenesis.
- Tumor metabolic reprogramming is a recognized hallmark of cancer.
Purpose of the Study:
- To summarize key genes and epigenetic regulators in CRC onset and progression.
- To clarify the role of gene expression and signaling pathways in tumor metabolism.
- To explore the crosstalk between epigenetic events and metabolic reprogramming in CRC.
Main Methods:
- Literature review and synthesis of current research on CRC genetics, epigenetics, and metabolism.
- Analysis of signaling pathways involved in tumor metabolic regulation.
- Integration of findings to explain CRC malignant progression.
Main Results:
- Identified key genes and epigenetic regulators driving CRC.
- Clarified the influence of gene expression and signaling on tumor metabolism.
- Highlighted the complex interplay between epigenetics and metabolic reprogramming in CRC.
Conclusions:
- The crosstalk between epigenetics and tumor metabolism is crucial for CRC progression.
- Understanding these mechanisms provides a comprehensive explanation for CRC malignancy.
- Integrating genetic, epigenetic, and metabolic targets offers promising strategies for CRC treatment.
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