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Resting-State Functional Connectivity Between the Cingulo-Opercular and Default Mode Networks May Explain
Shervin Assari1,2,3,4, Alexandra Donovan1, Golnoush Akhlaghipour4
1Department of Internal Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, United States.
Journal of Cellular Neuroscience
|March 10, 2025
Summary
Stable family structure and better educational opportunities are linked to improved youth cognition. This connection is explained by reduced functional connectivity between the Cingulo-Opercular Network (CON) and Default Mode Network (DMN).
Area of Science:
- Neuroscience
- Developmental Psychology
- Cognitive Science
Background:
- The Cingulo-Opercular Network (CON) and Default Mode Network (DMN) are key for executive control and cognitive regulation in youth.
- Resting-state functional connectivity (rsFC) between the CON and DMN is vital for task-switching and cognitive flexibility.
- Social determinants significantly impact cognitive development, but the underlying neural mechanisms require further investigation.
Purpose of the Study:
- To investigate if CON-DMN rsFC mediates the relationship between social determinants and cognitive outcomes in youth.
- To examine the specific roles of educational opportunities and family structure on cognitive performance via CON-DMN connectivity.
- To elucidate the neural pathways through which socioeconomic factors influence cognitive development.
Main Methods:
- Utilized data from the Adolescent Brain Cognitive Development (ABCD) study, including over 11,000 children (9-10 years).
- Assessed cognitive outcomes using NIH Toolbox measures and social determinants via parental education, family composition, and neighborhood data.
- Employed functional magnetic resonance imaging (fMRI) to measure CON-DMN rsFC and structural equation modeling (SEM) to test mediation effects.
Main Results:
- Stable family structure and increased educational opportunities were significantly associated with enhanced cognitive performance.
- These positive associations were mediated by reduced functional connectivity between the CON and DMN.
- The findings highlight a neural pathway linking social factors to cognitive abilities.
Conclusions:
- Reduced CON-DMN functional connectivity acts as a neural mechanism connecting social gradients to improved cognitive outcomes in youth.
- This study underscores the importance of social determinants in shaping brain function and cognitive development.
- Understanding these neural mechanisms can inform interventions aimed at mitigating socioeconomic disparities in cognitive health.
Keywords:
Cingulo-Opercular NetworkCognitionDefault Mode NetworkEducational OpportunitiesFamily StructureResting-State Functional ConnectivitySocial Determinants of HealthMore Related Videos
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