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Single Cell Multiplex Reverse Transcription Polymerase Chain Reaction After Patch-clamp

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Published on: June 20, 2018

Inhibitory and disinhibitory VIP IN-mediated circuits in neocortex.

Shlomo Dellal¹, Hector Zurita¹, Ilya Kruglikov¹

¹Neuroscience Institute, NYU Grossman School of Medicine, New York, NY, 10016.

Biorxiv : the Preprint Server for Biology

|March 10, 2025

Summary

This summary is machine-generated.

Vasoactive intestinal peptide (VIP) interneurons in the brain cortex are diverse. These VIP interneuron populations exhibit distinct properties and regulate neural activity differently, impacting cortical plasticity.

Keywords:

GABAergic microcircuits VIP interneurons cortical disinhibitory circuits endocannabinoid signaling interneuron diversity intersectional genetic targeting neocortical synaptic connectivity neuromodulatory control optogenetic manipulation somatosensory cortex

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Electrophysiological and Morphological Characterization of Neuronal Microcircuits in Acute Brain Slices Using Paired Patch-Clamp Recordings

Published on: January 10, 2015

Area of Science:

Neuroscience
Cellular Neuroscience
Cortical Circuitry

Background:

Cortical GABAergic interneurons expressing vasoactive intestinal peptide (VIP) are crucial for regulating neural activity.
VIP interneurons primarily inhibit somatostatin (SST) interneurons, leading to disinhibition of pyramidal cells (PCs) and cortical plasticity.
The functional significance of molecular diversity within VIP interneurons remains largely unknown.

Purpose of the Study:

To characterize the functional diversity of VIP interneurons in the primary somatosensory cortex (vS1).
To investigate the physiological significance of VIP interneuron heterogeneity.
To understand how different VIP interneuron subpopulations contribute to cortical circuit regulation.

Main Methods:

Utilized intersectional genetic approaches in the primary somatosensory cortex (vS1).
Characterized laminar distribution, axonal and dendritic morphology, and intrinsic electrophysiological properties.
Assessed efferent connectivity, activation by long-range inputs, and neuromodulation responses.

Main Results:

Identified four distinct VIP interneuron populations within vS1.
These populations differ in their anatomical distribution, connectivity, and electrophysiological profiles.
Observed differential activation by various inputs and neuromodulators (endocannabinoids, acetylcholine, noradrenaline).

Conclusions:

VIP interneurons represent a functionally diverse group with specialized roles in cortical processing.
These subpopulations exhibit distinct responses to external stimuli and neuromodulatory signals.
VIP interneuron subpopulations mediate specialized regulation of pyramidal cell activity and cortical network function.