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Updates in breathomics behavior in ischemic heart disease and heart failure, mass-spectrometry

Basheer Abdualah Marzoog1, Peter Chomakhidze2, Daria Gognieva2

  • 1Department of Cardiology, Sechenov University, Moscow 119991, Moskva, Russia. marzug@mail.ru.

World Journal of Cardiology
|March 10, 2025
PubMed

Insights

Exhaled breath analysis shows potential for diagnosing heart failure and ischemic heart disease (IHD). Further research is needed to understand volatile organic compounds (VOCs) as biomarkers for these conditions.

Area of Science:

  • Cardiology
  • Biomarker Discovery
  • Analytical Chemistry

Background:

  • Cardiovascular diseases (CVD), particularly ischemic heart disease (IHD) and heart failure, are leading global causes of disability and mortality.
  • Current diagnostic and management strategies for IHD and heart failure are insufficient, highlighting the need for improved early detection methods.
  • The role of early risk factor detection through modern strategies in CVD is underestimated and requires further investigation.

Purpose of the Study:

  • To review and interpret existing literature on volatile organic compounds (VOCs) in exhaled breath.
  • To analyze various methods used for breath analysis in patients diagnosed with IHD and heart failure.

Main Methods:

  • Systematic literature searches were conducted using Scopus and PubMed databases.
  • Keywords focused on breath analysis, IHD, and heart failure.
  • A total of 20 relevant studies were identified and included in the review. The study is registered in PROSPERO (CRD42023470556).

Main Results:

  • The current body of research on VOCs in IHD and heart failure is limited, necessitating further investigation for comprehensive understanding.
  • Existing studies indicate that metabolic alterations in the heart can be reflected in exhaled breath.
  • The scarcity of published articles poses significant challenges for data interpretation.

Conclusions:

  • Exhaled breath analysis presents a promising avenue as a novel biomarker for the diagnosis and prevention of heart failure and IHD.
  • Analysis of exhaled breath can serve as a non-invasive indicator, mirroring the metabolic changes associated with heart failure and IHD.
Abstract

Keywords:
Angina pectorisArrythmiaIschemic heart diseaseMass spectrometrySystemic review

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