Related Experiment Video
Updated: May 23, 2025
Construction of Vapor Chambers Used to Expose Mice to Alcohol During the Equivalent of all Three Trimesters of Human Development
Published on: July 13, 2014
Cytotoxic Effects of Srikhandasavam on Ethanol-Induced Neurotoxicity in Hippocampal Cell Cultures
S Kondamma1, J Kalaivannan1, Sumathi Jones2
1Department of Anatomy, Vinayaka Mission's Medical College, Karaikal, Vinayaka Mission's Research Foundation (Deemed to be University), Salem, Tamil Nadu, India.
Background:
Srikhandasavam is a traditional Ayurvedic herbal formulation known for its potential therapeutic properties, particularly in enhancing overall vitality and digestive health. It is composed of a blend of natural ingredients, including sandalwood, which are fermented to enhance their medicinal potency.
Aim:
The present study investigates the neuroprotective effects of Srikhandasavam on hippocampal neurons subjected to ethanol-induced neurotoxicity.
Methods:
The primary focus was to assess cell viability and cytotoxicity in the presence of Srikhandasavam at various concentrations, using hippocampal cell cultures.
Results:
The cytotoxicity results indicated a significant impact at higher concentrations, with 50.3% cell mortality observed at 200 µg/mL of Srikhandasavam. Conversely, the MTT assay revealed that Srikhandasavam offered notable protection against ethanol-induced neurotoxicity, with a 71.8% cell viability rate at the same 200 µg/mL concentration.
Conclusion:
These findings suggest that Srikhandasavam as a potential neuroprotective agent, capable of mitigating ethanol-induced damage in hippocampal neurons while maintaining cell viability at therapeutic concentrations.
More Related Videos
19:57The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
Published on: August 5, 2017
05:12Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
