Related Experiment Video For Lesions
Updated: Jul 10, 2026
Assessment of Perigenital Sensitivity and Prostatic Mast Cell Activation in a Mouse Model of Neonatal Maternal Separation
Published on: August 13, 2015
Assessment of Expression of Mast Cells Density in Oral Premalignant and Malignant Lesions by Histochemical Analysis
Mohammed Abidullah1, Bushra Anjum2, Shaikh Mohammed Imran Saudagar3
1Department of Biomedical Dental Sciences, Faculty of Dentistry, Al Baha University, AL Baha, Saudi Arabia.
Aim:
Assessment of mast cells density expression in oral premalignant and malignant lesions by histochemical analysis.
Materials And Methods:
The study used a total of 120 tissue blocks that were formalin-fixed and paraffin-embedded. These blocks consisted of 40 cases of oral squamous cell carcinoma (OSCC), 40 cases of oral epithelial dysplasia, and 40 cases of normal oral mucosa (NOM).
Results:
In the current investigation, a comparison was made between toluidine blue stained sections of normal oral mucosa, oral epithelial dysplasia and OSCC. The resultant P value was determined to be statistically insignificant in all three categories, namely, oral epithelial dysplasia, oral squamous cell carcinoma (OSCC), and normal oral mucosa. The resultant P values, calculated using an unpaired t-test, were shown to be extremely significant (P = 0.001).
Conclusion:
Research indicates that mast cells could be a significant marker for increased angiogenesis, which in turn could be used to predict carcinogenesis, its progression, and the prognosis of malignant lesions.
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