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Modulatory Effects of Gingerol in Cancer Cell Growth Through Activation and Suppression of Signal Pathways in Cancer

J Juvaid Noor1, R Sindhu2, A Banu Jothi2

  • 1Undergraduate (Bachelor of Dental Surgery), SRM Dental College, Chennai, Tamil Nadu, India.

Journal of Pharmacy & Bioallied Sciences
|March 10, 2025
PubMed
Abstract

Insights

Gingerol shows potential in cancer treatment by affecting cell growth pathways. Further research is needed to confirm its efficacy and mechanisms in human clinical trials.

Area of Science:

  • Oncology
  • Pharmacology
  • Natural Products

Background:

  • Gingerol, derived from the medicinal herb ginger, is traditionally used for cancer treatment.
  • This review focuses on gingerol's impact on cancer cell growth via key signaling pathways.

Purpose of the Study:

  • To explore gingerol's modulatory effects on cancer cell growth.
  • To investigate the activation and suppression of signaling pathways by gingerol in cancer progression.

Main Methods:

  • A systematic review of randomized control trials was conducted.
  • Databases searched included PubMed, Cochrane, Google Scholar, and Embase.
  • Seven articles published between 2011 and 2023 were included.

Main Results:

  • Gingerol demonstrated clinically significant improvements in quality of life related to chemotherapy-induced nausea and vomiting.
  • 6-Gingerol was found to inhibit prostate cancer cell viability and induce cell death in a time- and dose-dependent manner.
  • Gingerol may serve as a complementary therapy for ovarian cancer, enhancing outcomes and reducing toxicity with cisplatin.

Conclusions:

  • Gingerol exhibits potential in cancer treatment by modulating signaling pathways.
  • Further in-depth human clinical trials are necessary to validate gingerol's efficacy and elucidate its precise mechanisms in malignancy treatment.
Keywords:
Apoptosiscancer cell inhibitiongingerolmalignant cell inhibitionzingiber officinale

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