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Prognostic value of preoperative fibrinogen to albumin ratio in predicting postoperative outcomes in patients with

Peng-Fu Wang1, Ya-Jian Duan2

  • 1Department of General Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, Shanxi Province, China.

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Summary

Lower preoperative fibrinogen to albumin ratio (FAR) indicates better survival in gallbladder cancer (GBC) patients. This finding highlights FAR as a potential prognostic marker for GBC outcomes.

Keywords:
Fibrinogen to albumin ratioGallbladder cancerOverall survivalPrognostic biomarkerSurgical outcomes

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Area of Science:

  • Oncology
  • Biomarkers
  • Surgical Outcomes

Background:

  • Gallbladder cancer (GBC) presents a significant challenge due to its poor prognosis.
  • The preoperative fibrinogen to albumin ratio (FAR) is a potential prognostic marker for GBC, but its value needs further exploration.

Purpose of the Study:

  • To investigate the prognostic significance of preoperative FAR in predicting outcomes for GBC patients.

Main Methods:

  • A retrospective cohort study included 66 GBC patients who underwent curative surgery.
  • Preoperative FAR was measured within one week before surgery.
  • Overall survival (OS) was the primary endpoint, analyzed using ROC curves and Kaplan-Meier estimates.

Main Results:

  • An optimal FAR cut-off of 0.088 was identified with good diagnostic accuracy (AUC=0.7899).
  • Patients with lower FAR (≤ 0.088) demonstrated significantly longer median OS (25.6 months) compared to those with higher FAR (> 0.088; 10.8 months).

Conclusions:

  • Preoperative FAR is a valuable prognostic indicator in GBC.
  • Lower FAR is associated with improved overall survival, aiding in patient management and outcome prediction.