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Updated: May 23, 2025

Visualization of Streptococcus pneumoniae within Cardiac Microlesions and Subsequent Cardiac Remodeling
Published on: April 7, 2015
Streptococcus pneumoniae-Related Infective Endocarditis Complicated by Development of Psoas and Epidural Abscesses
Fatemeh Jafari Roshan-Zamir1,2, Shantell Ceaser3, Kristy Chin4
1Neurology, William Carey University College of Osteopathic Medicine, Hattiesburg, USA.
Abstract:
Streptococcus pneumoniae (S. pneumoniae), a gram-positive bacterium in the upper respiratory tract, can cause pneumonia, meningitis, and bloodstream infections. S. pneumoniae septicemia may lead to cardiac valve seeding, increasing the risk of epidural and psoas abscesses. Understanding its pathology is crucial for improving early detection and intervention. A 55-year-old male patient presented with fever, acute disorientation, and confusion. Initial broad-spectrum antibiotics were adjusted following positive blood cultures for S. pneumoniae. While meningitis was the primary concern, further imaging revealed mitral valve vegetation, an epidural abscess (L2-L4), osteomyelitis, and a psoas abscess. Due to an unsuccessful lumbar puncture, CSF analysis was not obtained. The patient received IV Ceftriaxone and Vancomycin and underwent a successful laminectomy, completing six weeks of antibiotics. This case highlights the severe complications of S. pneumoniae infective endocarditis, particularly its hematogenous spread leading to an epidural abscess. While cardiac valve seeding is well-documented, its role in epidural abscess formation is often overlooked. Given the diagnostic challenges of spinal epidural abscesses due to their resemblance to meningitis, accurate and timely diagnostics are critical for optimizing treatment and preventing deterioration.
Insights
Streptococcus pneumoniae septicemia can cause serious complications like epidural abscesses. This case highlights the importance of recognizing cardiac valve seeding
Area of Science:
- Infectious Diseases
- Neurology
- Cardiology
Background:
- Streptococcus pneumoniae (S. pneumoniae) is a common upper respiratory tract pathogen.
- S. pneumoniae can cause severe infections including pneumonia, meningitis, and bloodstream infections (septicemia).
- Septicemia from S. pneumoniae can lead to endocarditis and subsequent hematogenous spread.
Observation:
- A 55-year-old male presented with fever, disorientation, and confusion.
- Blood cultures confirmed S. pneumoniae septicemia.
- Imaging revealed mitral valve vegetation, an epidural abscess (L2-L4), osteomyelitis, and a psoas abscess.
Findings:
- The patient was treated with IV Ceftriaxone and Vancomycin.
- A laminectomy was performed for the epidural abscess.
- The patient completed six weeks of antibiotic therapy.
Implications:
- This case underscores the severe complications of S. pneumoniae infective endocarditis.
- Hematogenous spread from cardiac valve seeding can lead to epidural abscesses.
- Timely diagnosis is critical for managing S. pneumoniae-related epidural abscesses, which can mimic meningitis.
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