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Unexpected Primaquine-Induced Hemolysis in a G6PD-Normal Patient: A Case Report From Nepal
Aarju Khadka1, Sachet Subedi2, Nisha Lama1
1College of Medical Sciences Teaching Hospital Bharatpur Nepal.
Abstract:
Primaquine, an antimalarial drug, is essential for preventing relapses of Plasmodium vivax. However, it poses a risk of hemolytic anemia, particularly in glucose-6-phosphate dehydrogenase (G6PD) deficient patients. This case report details a 27-year-old male with normal G6PD levels who developed hemolytic anemia following primaquine therapy for P. vivax malaria. Despite a normal quantitative G6PD analysis, the patient experienced a significant drop in hemoglobin, necessitating early discontinuation of the drug. This case highlights the potential for hemolysis in G6PD-normal patients, underscoring the importance of close monitoring and the limitations of current G6PD screening methods.
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