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Persistent aura without infarction.

Maurizio Severino1, Mark W Green2

  • 1Pain Outpatient Clinic, Department of Anaesthesia and Intensive Care, Akershus University Hospital, Nordbyhagen, Norway.

Current Opinion in Neurology
|March 10, 2025
PubMed
Summary
This summary is machine-generated.

Persistent aura without infarction is a rare neurological condition requiring careful diagnosis. Treatments like zonisamide and ketamine may offer benefits, but more research is needed.

Keywords:
acetazolamidecortical spreading depressioncortisonefurosemideketaminemigraine aurapersistent migraine without infarctionvalproic acidzonisamide

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Area of Science:

  • Neurology
  • Neuro-ophthalmology
  • Psychiatry

Background:

  • Persistent aura without infarction is a rare, disabling condition with complex diagnostic considerations.
  • It presents a diagnostic challenge, potentially linked to cortical spreading depression and vasoconstriction.
  • Accurate differential diagnosis is crucial to guide appropriate treatment and prevent complications.

Purpose of the Study:

  • To review the available literature on persistent aura without infarction.
  • To summarize the current understanding of this rare neurological condition.
  • To highlight the importance of differential diagnosis for effective management.

Main Methods:

  • Literature review of persistent aura without infarction.
  • Analysis of diagnostic challenges and clinical features.
  • Summary of potential therapeutic approaches.

Main Results:

  • Persistent aura without infarction poses diagnostic difficulties, with features not always fitting established criteria.
  • Diagnosis necessitates excluding other conditions like infarction, epilepsy, and psychiatric disorders.
  • Certain medications like triptans may be harmful, while others such as acetazolamide, valproic acid, zonisamide, furosemide, cortisone, and ketamine might be beneficial.

Conclusions:

  • Persistent aura without infarction is a challenging diagnosis.
  • Therapeutic strategies involving zonisamide and ketamine show potential benefit.
  • Further randomized controlled trials are essential to elucidate pathogenesis and optimize treatment.