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Microfluidics in Assessing Platelet Function
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Cold Stored Platelets: A Solution for Platelet Aggregation External Quality Assessment/Proficiency Testing.

Christopher Reilly-Stitt1, Ian Jennings1, Steve Kitchen1

  • 1UK NEQAS (Blood Coagulation), Sheffield, UK.

International Journal of Laboratory Hematology
|March 10, 2025
PubMed
Summary
This summary is machine-generated.

Fresh donor platelets can be used for external quality assessment (EQA) in light transmission aggregometry (LTA) for platelet function testing. This method ensures accurate interpretation of platelet aggregation traces across different laboratory platforms.

Keywords:
cold‐stored plateletsexternal quality assessmentlight transmission aggregation

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Area of Science:

  • Clinical Pathology
  • Hematology
  • Laboratory Medicine

Background:

  • ISO 15189 accreditation requires participation in external quality assessment (EQA) or internal comparisons.
  • Light transmission aggregometry (LTA) for platelet function testing is time-dependent.
  • Current EQA primarily assesses the interpretation of platelet aggregation traces.

Purpose of the Study:

  • To evaluate the feasibility of using fresh donor platelets for EQA in LTA.
  • To assess if fresh donor platelets can audit analytical and post-analytical aspects of LTA.
  • To determine if NEQAS BC can provide suitable EQA material for LTA.

Main Methods:

  • A pool of donor platelets was prepared and distributed to testing centers.
  • Centers performed LTA assays using their validated methods within a 72-hour window.
  • Agonists tested included ADP, Arachidonic acid, Collagen, Epinephrine, Ristocetin, TRAP, and U46619.

Main Results:

  • Five different aggregometry platforms were utilized by participating centers.
  • Most sites performed LTA on the EQA material on the first day of distribution.
  • Sample packs remained stable for testing within the 72-hour window.

Conclusions:

  • High consensus (94-100%) was achieved in the interpretation of platelet aggregation traces for key agonists.
  • The fresh donor platelet material proved stable for EQA purposes.
  • Different aggregometers yielded consistent clinical interpretations, validating the EQA approach.