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Characterization of Sickling During Controlled Automated Deoxygenation with Oxygen Gradient Ektacytometry
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Exploring Posturography in Children with Sickle Cell Disease.

Victoria G Marchese1, Emily McCarthy1, Simon Ho1

  • 1Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, MD, USA.

Physical & Occupational Therapy in Pediatrics
|March 10, 2025
PubMed
Summary
This summary is machine-generated.

Children with sickle cell disease (SCD) show impaired balance but not postural control deficits compared to peers. Further research is needed to understand this dissociation in motor skills.

Keywords:
Balancepostural controlsickle cell disease

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Area of Science:

  • Pediatric Health
  • Neurology
  • Motor Control

Background:

  • Sickle cell disease (SCD) impacts 1 in 350 US newborns.
  • Children with SCD face risks for impaired postural control.
  • This study investigates balance and postural control in children with SCD.

Purpose of the Study:

  • To compare postural control in children with SCD versus controls.
  • To assess balance using standardized motor proficiency tests.
  • To evaluate sensory integration and limits of stability in pediatric SCD.

Main Methods:

  • Twenty-eight children (6-17 years) with SCD and matched controls participated.
  • Posturography assessed Limits of Stability (LOS) and mCTSIB.
  • Balance was measured using the Bruininks-Oseretsky Test of Motor Proficiency, 2nd Edition (BOT-2).

Main Results:

  • No significant differences in posturography measures (LOS, mCTSIB) between groups.
  • Children with SCD exhibited significantly poorer BOT-2 balance scores (p < 0.001).

Conclusions:

  • Children with SCD show impaired balance but intact posturography.
  • The dissociation between balance and postural control in pediatric SCD requires further investigation.