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Related Concept Videos

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Related Experiment Video

Updated: May 23, 2025

3-D Cell Culture System for Studying Invasion and Evaluating Therapeutics in Bladder Cancer
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PRR11 Promotes Bladder Cancer Growth and Metastasis by Facilitating G1/S Progression and Epithelial-Mesenchymal

Lu Wang1,2,3, Zengshun Kou1,2, Jiaxi Zhu4

  • 1Department of Urology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China.

Cancer Medicine
|March 10, 2025
PubMed
Summary

Proline-rich Protein 11 (PRR11) is upregulated in bladder cancer, promoting tumor growth and metastasis. Silencing PRR11 inhibits cancer progression by affecting the cell cycle and epithelial-mesenchymal transition, offering a potential therapeutic target.

Keywords:
PRR11biomarkersbladder cancercell cycletumor treatment

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Abnormalities in Proline-rich Protein 11 (PRR11) are linked to cancer development.
  • The specific role of PRR11 in bladder cancer progression is not fully understood.

Purpose of the Study:

  • To investigate the molecular mechanisms of PRR11 in bladder cancer.
  • To determine the prognostic value of PRR11 in bladder cancer patients.

Main Methods:

  • Differential gene expression analysis using TCGA and GEO databases.
  • In vitro and in vivo experiments to assess PRR11 function.
  • Gene Set Enrichment Analysis (GSEA) to identify downstream pathways.

Main Results:

  • PRR11 is upregulated in bladder cancer and associated with poor prognosis.
  • PRR11 promotes tumor cell proliferation, growth, and metastasis via Epithelial-mesenchymal Transition (EMT).
  • PRR11 knockdown inhibits tumor growth by affecting the cell cycle (CCNE, G1/S transition).

Conclusions:

  • Silencing PRR11 inhibits bladder cancer progression by suppressing EMT and cell cycle transition.
  • Targeting PRR11 presents a novel strategy for bladder cancer cell cycle therapy.