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Updated: May 23, 2025

Metal-free Synthesis of Ynones from Acyl Chlorides and Potassium Alkynyltrifluoroborate Salts
Published on: February 24, 2015
Computational exploration of vinyl sulfoxonium ylide chemistry
Dinesh Kumar Gopalakrishnan1, Janakiram Vaitla1, Tarak Karmakar1
1Department of Chemistry, Indian Institute of Technology Delhi, Hauz Khas, New Delhi 110016, India. vaitla@chemistry.iitd.ac.in.
Abstract:
This review comprehensively examines the computational techniques employed to elucidate the reactivity, selectivity, and mechanistic pathways of vinyl sulfoxonium ylides. By delving into a spectrum of reactions ranging from insertion and cycloaddition to annulation, multicomponent reactions, and carbene-mediated transformations, we demonstrate the pivotal role of computational techniques in understanding the mechanism, reactivity and selectivity. The synergy between experimental and computational approaches is emphasized as a driving force for future breakthroughs and the continuous evolution of this dynamic and emerging field.
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