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Evolution of lymphovascular space invasion in early-stage endometrial carcinoma: stratification, quantification, and clinical implications: a systematic review

  • 0Department of Obstetrics and Gynecology, Hebei Medical University, Fourth Hospital, Jiankanglu 12, Shijiazhuang, 050011, China. 13582117716@163.com.
Archives of Gynecology and Obstetrics +

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March 10, 2025

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March 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Lymphovascular space invasion (LVSI) is a key prognostic factor in endometrial cancer (EC). Refined classification and quantification of LVSI are crucial for improving risk stratification and patient management in early-stage EC.

Area Of Science

  • Gynecologic Oncology
  • Pathology
  • Clinical Research

Background

  • Endometrial carcinoma (EC) is the most common female genital tract malignancy in the US.
  • Lymphovascular space invasion (LVSI) is a critical prognostic factor influencing EC outcomes.
  • Understanding LVSI is vital for accurate risk stratification and treatment decisions in early-stage EC.

Purpose Of The Study

  • To review the evolving understanding of LVSI in early-stage EC.
  • To highlight LVSI's implications for stratification, quantification, and clinical management.
  • To synthesize current knowledge on LVSI in endometrial cancer.

Main Methods

  • Systematic review adhering to PRISMA guidelines.
  • Searched PubMed, Web of Science, and Embase/MEDLINE databases (1985-2024).
  • Included peer-reviewed articles reporting multivariable hazard ratios for LVSI in EC.

Main Results

  • Included 6 studies with 2,345 patients; 85.7% endometrioid histotype, 75.1% FIGO stage I.
  • LVSI was present in 21.5% of cases; 62.4% received adjuvant treatment.
  • Literature categorized into stratification, quantification, and guideline development, showing progression to tiered classifications.

Conclusions

  • LVSI is a significant risk factor in EC, with refined classification and quantification over time.
  • Inconsistencies in LVSI thresholds across guidelines hinder standardization.
  • Future multicenter studies and new technologies are needed to improve risk stratification and management.

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