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Evaluation of Circulating Glypican-4 in Patients with ESKD

Axel Muendlein1, Eva Maria Brandtner1, Judith Schimpf2

  • 1Vorarlberg Institute for Vascular Investigation and Treatment, Feldkirch, Austria.

Kidney360
|March 10, 2025
PubMed

Insights

Serum Glypican-4 (GPC4) is significantly elevated in patients starting dialysis, correlating with kidney disease markers. However, elevated GPC4 did not predict mortality in this end-stage kidney disease population.

Area of Science:

  • Nephrology
  • Biochemistry
  • Proteoglycan Research

Background:

  • Glypican-4 (GPC4) is a cell-surface proteoglycan found in circulation.
  • Elevated GPC4 is linked to reduced kidney function and increased mortality risk.
  • The role of GPC4 in end-stage kidney disease (ESKD) prognosis was unexplored.

Purpose of the Study:

  • To investigate the potential of circulating GPC4 in assessing disease status and prognosis in patients with ESKD.
  • To explore the association of GPC4 with clinical parameters in patients initiating dialysis.

Main Methods:

  • Study included 187 incident dialysis patients and 108 controls.
  • Serum GPC4 levels measured via ELISA before dialysis initiation.
  • Follow-up for incident dialysis patients averaged 3.8 years.

Main Results:

  • Serum GPC4 was ~10-fold higher in dialysis patients vs. controls.
  • GPC4 correlated positively with creatinine and phosphate.
  • GPC4 correlated negatively with eGFR, hemoglobin, erythrocytes, calcium, and cholinesterase.
  • No significant association found between GPC4 and all-cause mortality.

Conclusions:

  • GPC4 levels are markedly elevated in patients starting dialysis.
  • Elevated GPC4 is associated with pathophysiological characteristics of ESKD.
  • GPC4 is not a significant predictor of all-cause mortality in this population.
Abstract

No abstract available in PubMed .

Keywords:
ESKDbiomarkersdialysisepidemiology and outcomeskidney dysfunctionkidney failurelongitudinal data analysismolecular biologymortalityrisk factors

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