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Familial meconium ileus with normal sweat electrolytes
Clinical Pediatrics
|August 1, 1985
Insights
Meconium ileus (MeI) is a common sign of cystic fibrosis (CF) in infants. However, this report details four siblings with MeI but no signs of CF, suggesting alternative causes.
Area of Science:
- Pediatric Gastroenterology
- Genetics
- Neonatal Medicine
Background:
- Meconium ileus (MeI) is a significant indicator of cystic fibrosis (CF) in newborns, affecting 10-15% of infants with the condition.
- MeI in the absence of CF is exceptionally rare, posing diagnostic challenges.
Abstract:
Meconium ileus (MeI) is the presenting symptom in 10 to 15 percent of infants with cystic fibrosis (CF), but it is a rare phenomenon in patients who do not have this disease. We report four Bedouin siblings who had MeI with no laboratory evidence of CF.