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Published on: February 11, 2017
Reverse Potts shunt in severe pulmonary hypertension: A 20-year retrospective review
Wei Jiang1, Zhongshi Wu1, Can Huang1
1Department of Cardiovascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Insights
Reverse Potts shunt (RPS) offers a promising treatment for pediatric pulmonary arterial hypertension (PAH), improving cardiac function and survival. Further research is needed to optimize patient selection and technique for this innovative therapy.
Area of Science:
- Cardiology
- Pediatric Cardiology
- Surgical Interventions
Background:
- Pulmonary arterial hypertension (PAH) in children leads to right heart failure, with unsatisfactory outcomes despite advances.
- PAH-specific therapies have improved management, but prognosis remains a concern for many pediatric patients.
Purpose of the Study:
- To review the clinical experience and efficacy of reverse Potts shunt (RPS) in treating pediatric pulmonary arterial hypertension (PAH).
- To discuss challenges and guide clinical practice for RPS in PAH management.
Main Methods:
- Retrospective summary of accumulated clinical experience with RPS over the past 20 years.
- Analysis of RPS application in pediatric PAH patients.
Main Results:
- RPS effectively improves cardiac function and survival time in PAH patients.
- Midterm survival rates with RPS are comparable to lung transplantation.
- RPS alleviates right heart burden by creating a shunt between the pulmonary artery and descending aorta.
Conclusions:
- RPS is a valuable palliative option for pediatric PAH, offering improved outcomes.
- Challenges include identifying suitable patients, optimal timing, and shunt selection.
- Further refinement of RPS techniques and patient selection criteria is crucial for broader clinical application.
Abstract:
Pulmonary arterial hypertension (PAH) is a multifactorial heterogeneous condition characterized by elevated pulmonary artery pressure, leading to increased right ventricular afterload and ultimately resulting in right heart failure. Despite major advances in the management of pediatric PAH in recent years with the development of PAH-specific drug therapy and therapeutic strategies, prognosis still remains unsatisfactory for many children. The Potts shunt, as a palliation in patients with cyanotic congenital heart defects first, receives its 'second life' in treating PAH by creating a shunt between the pulmonary artery and the descending aorta to alleviate right heart burden. Over the past 20 years, accumulated clinical experience have revealed that reverse Potts shunt (RPS) can effectively improve cardiac function and survival time in PAH patients, with midterm survival rates comparable to those of lung transplantation. However, RPS is confronted with some issues that limit its development and application in clinical practice, such as identifying the suitable patient population, determining the optimal timing of intervention, and selecting the appropriate shunt type and size. This review aims to retrospectively summarize the experience of RPS in the treatment of PAH, discuss the main challenges faced in its clinical application, and help to guide clinical practice.
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