Synthesis and characterization of MIL-101(Fe) nanoparticle and Patchouli alcohol composites as a antimicrobial agents
Qiaowen Wang1, Xiao Huang1, Dingjun Wang1
1School of Public Health, Guangdong Pharmaceutical University, Guangzhou, 510310, China.
Background:
Multidrug-resistant Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are emerging in large numbers, while the rapid development of antimicrobial nanomaterials offers new opportunities to combat bacterial infections and antimicrobial resistance.
Objectives:
We employed the nanomaterial MIL-101(Fe) as a carrier loaded with Patchouli alcohol (PA) to form the complex MIL-101(Fe)-PA. and to investigate the inhibitory activity of MIL-101(Fe)-PA against S. aureus and E. coli.
Methods:
According to the literature,we prepared MIL-101(Fe)-PA by solvent method. Characterization of MIL-101(Fe)-PA was carried out using scanning electron microscopy(SEM), Fourier transform infrared(FT-IR) spectroscopy,X-ray diffractometer (XRD) and Brunauer-Emmett-Teller (BET) adsorption analysis. In the bacteriostatic experiments,its bacteriostatic effect was investigated by Minimal inhibitory concentration (MIC) experiments, cell proliferation,and growth curves of bacteria. Then its cytotoxicity was explored by cytotoxicity experiments.
Results:
The characterization results indicated that we successfully prepared the complex MIL-101(Fe)-PA,which showed significant bacteriostatic effects against S. aureus and E. coli at 2 mg/mL. The inhibitory effect was stronger than that of MIL-101(Fe) as well as PA.
Conclusion:
It shows that MIL-101(Fe)-PA has excellent inhibitory effect on S. aureus and E. coli.
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