Plasmodium falciparum and immune phagocytosis: characterization of the process

Phagocytosis is a critical immunological process that enables the immune system to recognize and eliminate foreign pathogens and self-derived pathogenic molecules. Improving the overall understanding of this immune mechanism during malarial infection is imperative. The mechanisms by which phagocytosis eradicates malaria parasites, particularly Plasmodium falciparum, remain incompletely understood and warrant further investigation. In this context, previous studies have shown that various factors such as phagocyte cell subclasses, plasma protein molecules and Plasmodium evasion tactics influence the phagocytic process differently. However, the mechanisms underlying phagocytic activity during P. falciparum infections are still ambiguous. In this review, we summarize key immunological aspects and current knowledge of phagocytic activity during P. falciparum infection. We highlight the significant involvement of distinct active cells that induce phagocytosis. Additionally, we discuss the implications of phagocytosis and potential therapeutic approaches to enhance its effectiveness.