Water Soluble Thermoresponsive Single-Chain Cyclized/Knotted Polymers from Intramolecular Cyclization Dominated
Zishan Li1, Jing Lyu1, Yinghao Li1
1Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Dublin, D04 V1W8, Ireland.
Abstract:
A series of water-soluble, PEG-based single-chain cyclized/knotted polymers are successfully synthesized through the homopolymerization of poly(ethylene glycol) diacrylate (PEGDA) (Mn = 575 and 700 g mol-1, respectively) via enhanced intramolecular cyclization. The homopolymerization of the diacrylate macromers first proceeds through linear propagation, followed by self-cyclization. Under high monomer-to-initiator ratios (e.g., 100-500) and room temperature, cyclized polymers with high cyclized ratios of up to 70% are achieved without gelation. Notably, the cyclized poly(PEGDA575) exhibits concentration-dependent thermoresponsive properties in aqueous solutions.
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