Association between life's essential 8 and diabetic kidney disease: a population-based study

Area of Science:

• Cardiology
• Nephrology
• Public Health

Background:

• Diabetic patients face high risks for cardiovascular and renal diseases.
• Life's essential 8 (LE8) is a new index for cardiovascular health (CVH).
• LE8 may help assess diabetic kidney disease (DKD) risk.

Purpose of the Study:

• To explore the relationship between LE8 and DKD in diabetic patients.
• To provide evidence for clinical strategies in managing DKD.
• To assess the association of LE8 subscales with DKD risk.

Main Methods:

• Analysis of 3,715 participants from NHANES, representing 18.9 million US residents.
• Adjusted for confounding factors to determine DKD risk associated with LE8 scores.
• Used restricted cubic spline regression to analyze the LE8-DKD relationship.

Main Results:

• A weighted DKD prevalence of 36.39% was found among diabetic patients.
• Higher LE8 scores significantly correlated with lower DKD risk (OR 0.54 for moderate, OR 0.18 for high).
• A linear relationship was observed between LE8 scores and DKD risk.

Conclusions:

• Elevated LE8 scores are associated with a decreased risk of developing DKD.
• LE8 and its subscales show potential as tools for DKD risk assessment.
• Further prospective studies are needed to confirm the long-term causal relationship.