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Updated: May 23, 2025

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility
Published on: April 5, 2024
Mitochondrial Involvement in the Pathogenesis of Endometriosis and its Potential as Therapeutic Targets
DongYi Shen1, Cong Qi1, PanWei Hu1
1Department of Gynaecology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Abstract:
Endometriosis is an estrogen-dependent benign disease characterized by the development of endometrial tissue outside the uterus. This intricate ailment markedly affects a patient's well-being and lacks a definitive cure. Endometriotic cells enhance their viability by modulating genetic and epigenetic characteristics, with mitochondria being important organelles in determining cellular metabolic pathways. Mitochondrial malfunction is associated with various human disorders, and the disruption of mitochondrial adaptation mechanisms may help develop new therapies for endometriosis. This article examines the significance of mitochondrial balance in the etiology and advancement of endometriosis and introduces several potential drugs targeting mitochondria for its treatment.
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