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Updated: May 23, 2025
Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
Cell death in tumor microenvironment: an insight for exploiting novel therapeutic approaches
Wenxin Wang1,2,3, Tong Li1,2,3, Kui Wu4,5,6
1BGI Genomics, Shenzhen, 518083, China.
Abstract:
Cell death is critical in tumor biology. The common cancer therapies can cause cell death and alleviate tumor, while the cancer cells can develop a resistance to cell death and survive from the therapies. Thus, not only observing the alternative mechanisms of tumor cells resistant to cell death, but also understanding the intricate dynamics of cell death processes within the tumor microenvironment (TME), are essential for tailoring effective therapeutic strategies. High-throughput sequencing technologies have revolutionized cancer research by enabling comprehensive molecular profiling. Recent advances in single cell sequencing have unraveled the heterogeneity of TME components, shedding light on their complex interactions. In this review, we explored the interplay between cell death signaling and the TME, summarised the potential drugs inducing cell death in pre-clinical stage, reviewed some studies applying next-generation sequencing technologies in cancer death research, and discussed the future utilization of updated sequencing platforms in screening novel treatment methods targeted cell death. In conclusion, leveraging multi-omics technologies to dissect cell death signaling in the context of the TME holds great promise for advancing cancer research and therapy development.
Insights
Understanding cancer cell death resistance and tumor microenvironment (TME) dynamics is key for effective cancer therapies. Advanced sequencing technologies help explore cell death signaling for novel treatment strategies.
Area of Science:
- Oncology
- Molecular Biology
- Immunology
Background:
- Cell death is a critical process in tumor biology, targeted by cancer therapies.
- Cancer cells can develop resistance to cell death, leading to therapeutic failure.
- The tumor microenvironment (TME) plays a complex role in regulating cell death and therapy response.
Purpose of the Study:
- To explore the interplay between cell death signaling and the TME in cancer.
- To summarize pre-clinical drugs that induce cell death.
- To review the application of next-generation sequencing (NGS) in cancer death research and discuss future directions.
Main Methods:
- Literature review of studies on cell death, TME, and sequencing technologies in cancer.
- Exploration of mechanisms of cancer cell death resistance.
- Analysis of advances in single-cell sequencing for TME heterogeneity.
Main Results:
- Cancer cell death resistance and TME dynamics are crucial for therapeutic outcomes.
- Several pre-clinical drugs targeting cell death pathways have been identified.
- NGS technologies offer powerful tools for dissecting TME complexity and identifying novel therapeutic targets.
Conclusions:
- Understanding cell death signaling within the TME is essential for developing effective cancer treatments.
- Multi-omics approaches, particularly advanced sequencing, hold significant promise for identifying new cell death-targeted therapies.
- Future research should focus on leveraging these technologies to personalize cancer treatment strategies.
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