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Updated: May 23, 2025

An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
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The m6A reader IGF2BP3 promotes HCC progression by enhancing MCM10 stability

Lianwu Zhao1, Hongyan Huang1, Linfei Luo1

  • 1Department of Gastroenterology, The 2nd Affiliated Hospital, Jiangxi Medical College, Nanchang University, Jiangxi, 330000, People's Republic of China.

Scientific Reports
|March 11, 2025
PubMed
Summary

Abnormal N6-methyladenosine (m6A) modifications are linked to cancer. Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) promotes liver cancer progression by stabilizing m6A-modified RNA, indicating its potential as a therapeutic target.

Keywords:
HCCIGF2BP3MCM10m6A modification

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