Intermittent theta burst stimulation (iTBS) and inhibitory control training for excess weight treatment: study...

Area of Science:

• Neuroscience
• Behavioral Science
• Public Health

Background:

• Global rise in excess weight necessitates novel interventions.
• Conventional weight management (diet, exercise) shows limited long-term effectiveness.
• Impulsive eating behavior, influenced by environment, is a key factor in excess weight.

Purpose of the Study:

• To evaluate the efficacy of inhibitory control training (ICT) combined with intermittent theta-burst stimulation (iTBS) for excess weight management.
• To assess iTBS alone and in combination with ICT as adjuncts to standard weight loss treatment.
• To explore the impact on eating behaviors, brain function, and physiological markers.

Main Methods:

• A parallel-group, randomized controlled trial involving 141 participants with excess weight.
• Three arms: combined ICT + iTBS, iTBS alone, and sham iTBS, all with standard care (diet and exercise).
• Interventions delivered over ten sessions within two weeks, with assessments at baseline, post-intervention, and 3-month follow-up.

Main Results:

• Primary outcome: change in Body Mass Index (BMI).
• Secondary outcomes: changes in brain connectivity (fMRI), cognitive function, eating/exercise behaviors, and biological markers.
• Cost-effectiveness and cost-utility analyses will be conducted.

Conclusions:

• This trial will provide evidence on the effectiveness of cognitive and neuromodulation interventions for excess weight.
• Findings may inform new therapeutic strategies targeting eating behavior regulation.
• The study aims to expand knowledge on neuroscience-based approaches for weight management.