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Updated: May 23, 2025
Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
Published on: March 15, 2024
[Research progress on the role and mechanism of ferroptosis in heart diseases]
Yu-Tong Cui1, Xin-Xin Zhu1, Qi Zhang1
1Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China.
Insights
Ferroptosis, an iron-dependent cell death, is crucial in cardiovascular diseases. Targeting ferroptosis mechanisms offers potential therapeutic strategies for various heart conditions.
Area of Science:
- Cardiology
- Cell Death Mechanisms
- Biochemistry
Background:
- Cardiovascular disease is a leading cause of death in China, with rising incidence.
- Ferroptosis, a form of iron-dependent cell death, is implicated in numerous heart conditions.
- Understanding ferroptosis is critical for developing novel cardiovascular therapies.
Purpose of the Study:
- To review recent advances in ferroptosis mechanisms.
- To explore the role of ferroptosis in various heart diseases.
- To discuss ferroptosis-targeting therapeutics for cardiovascular disease.
Main Methods:
- Literature review of ferroptosis mechanisms.
- Analysis of ferroptosis involvement in heart failure, ischemia/reperfusion injury, diabetic cardiomyopathy, doxorubicin cardiotoxicity, septic cardiomyopathy, and arrhythmia.
- Discussion of therapeutic potential of ferroptosis inhibitors/inducers.
Main Results:
- Ferroptosis involves iron metabolism, oxidative stress, lipid peroxidation, and other pathways.
- Ferroptosis plays a significant role in diverse cardiovascular pathologies.
- Emerging evidence highlights ferroptosis as a key intervention target for heart diseases.
Conclusions:
- Ferroptosis is a critical mediator in cardiovascular disease.
- Targeting ferroptosis pathways presents promising therapeutic avenues for heart conditions.
- Further research into ferroptosis modulation could revolutionize cardiovascular disease treatment.
Abstract:
Cardiovascular disease remains the leading cause of death in China, with its morbidity and mortality continue to rise. Ferroptosis, a unique form of iron-dependent cell death, plays a major role in many heart diseases. The classical mechanisms of ferroptosis include iron metabolism disorder, oxidative antioxidant imbalance and lipid peroxidation. Recent studies have found many additional mechanisms of ferroptosis, such as coenzyme Q10, ferritinophagy, lipid autophagy, mitochondrial metabolism disorder, and the regulation by nuclear factor erythroid 2-related factor 2 (NRF2). This article reviews recent advances in understanding the mechanisms of ferroptosis and its role in heart failure, myocardial ischemia/reperfusion injury, diabetic cardiomyopathy, myocardial toxicity of doxorubicin, septic cardiomyopathy, and arrhythmia. Furthermore, we discuss the potential of ferroptosis inhibitors/inducers as therapeutic targets for heart diseases, suggesting that ferroptosis may be an important intervention target of heart diseases.
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