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Updated: May 23, 2025

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
Published on: June 23, 2023
Acute Ethanol-Disulfiram Reaction Presenting With Hemodynamic Instability: A Case Report
Mariana Estrela Santos1, Francisca Carmo1, João Miranda1
1Internal Medicine, Unidade Local de Saúde Gaia Espinho, Vila Nova de Gaia, PRT.
Abstract:
Ethanol-disulfiram reaction (EDR) is a rare but potentially life-threatening condition characterized by a constellation of symptoms, including flushing, hypotension, tachycardia, nausea, and vomiting. We report the case of a 52-year-old male patient who presented with acute hemodynamic instability after inadvertent alcohol consumption while on disulfiram therapy for alcohol dependence. The patient exhibited signs of shock, including hypotension and hyperlactatemia, but responded promptly to fluid resuscitation and transient vasopressor support. A detailed history confirmed the diagnosis of EDR. This case highlights the importance of recognizing EDR as a differential diagnosis in patients with acute hemodynamic instability and a relevant clinical history. Early identification and supportive management are crucial for favorable outcomes.
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