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Related Concept Videos

Radiological Investigation II: MRI and Ventilation Perfusion Scan01:30

Radiological Investigation II: MRI and Ventilation Perfusion Scan

Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...

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Related Experiment Video

Updated: Jun 17, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
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Optimizing Hepatocellular Carcinoma Screening: A Comparative Simulated Abbreviated MRI Protocol Study.

Yasam Preethi1, Amber S Papalkar1, Sandeep Ponnaganti1

  • 1Department of Radiology, Krishna Institute of Medical Sciences, Secunderabad, IND.

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|March 11, 2025
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Summary

Abbreviated non-contrast MRI (aNC-MR) and abbreviated dynamic multiphase contrast-enhanced MRI (aDCE-MRI) show high accuracy for hepatocellular carcinoma (HCC) screening. These efficient MRI protocols can reduce costs and time for high-risk patients.

Keywords:
abbreviated protocolcirrhosisdynamic contrast-enhanced mri (dce-mri)hbvhepatocellular carcinomahepatocellular carcinoma screeningli-radsmri liveronco-imaging

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Area of Science:

  • Radiology and Medical Imaging
  • Hepatology
  • Oncology

Background:

  • Hepatocellular carcinoma (HCC) is a common complication of chronic liver diseases, often diagnosed at advanced stages.
  • Effective HCC surveillance is crucial for reducing mortality, with MRI being a preferred modality due to ultrasound's limitations.
  • Risk factors for HCC include viral hepatitis, cirrhosis, and metabolic-associated fatty liver disease.

Purpose of the Study:

  • To evaluate the per-lesion performance of simulated abbreviated non-contrast MRI (aNC-MR) versus conventional complete MRI (cMR) for HCC screening.
  • To assess the per-lesion performance of simulated abbreviated dynamic multiphase contrast-enhanced MRI (aDCE-MRI) versus cMR for HCC screening.
  • To determine the efficacy of abbreviated MRI protocols in patients with hepatic steatosis.

Main Methods:

  • Retrospective study at a single tertiary care center including high-risk HCC patients over five years.
  • Two abbreviated MRI protocols (aNC-MR and aDCE-MR) were simulated and compared to conventional complete MRI (cMR).
  • Two independent radiologists assessed lesion characterization using blinded review of abbreviated image sets.

Main Results:

  • The aNC-MR protocol demonstrated an 88% overall sensitivity, with 96.4% negative predictive value and 96.4% specificity compared to cMR.
  • The aDCE-MR protocol showed a 100% negative predictive value and 98.6% specificity compared to cMR.
  • Comparable performance was observed in patients with hepatic steatosis.

Conclusions:

  • Abbreviated non-contrast MRI (aNC-MR) is an effective and efficient modality for HCC screening, reducing time and cost.
  • Abbreviated dynamic multiphase contrast-enhanced MRI (aDCE-MRI) also demonstrates high diagnostic performance for HCC surveillance.
  • These abbreviated MRI protocols offer a viable alternative for screening high-risk individuals, including those with hepatic steatosis.