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Updated: May 23, 2025

Author Spotlight: Advancing Hepatic Fibrosis Diagnosis Using Magnetic Resonance Elastography and AI

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Published on: July 21, 2023

Modeling Liver Fibrosis Progression in Patients With Viral Hepatitis Using the Machine Learning Tool Subtype and

Akiyoshi Suzuki¹, Katsuhiro Sano¹, Yuya Saito¹

¹Department of Radiology, Juntendo University Graduate School of Medicine, Tokyo, JPN.

|March 11, 2025

Summary

This summary is machine-generated.

This study reveals the sequence of biomarker changes in liver fibrosis progression for hepatitis B virus (HBV) and hepatitis C virus (HCV) patients. Serum markers change first, followed by imaging biomarkers, leading to liver atrophy.

Keywords:

cirrhosis hepatitis b virus hepatitis c virus liver fibrosis subtype and stage inference sustain

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Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

Area of Science:

Hepatology
Biomarker Discovery
Machine Learning in Medicine

Background:

Liver fibrosis progression and biomarker changes are not fully understood.
Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major causes of liver disease.
Novel tools are needed to elucidate disease progression patterns.

Purpose of the Study:

To investigate liver fibrosis progression in HBV and HCV patients.
To identify patterns of biomarker changes during disease progression.
To utilize the machine learning tool Subtype and Stage Inference (SuStaIn).

Main Methods:

Retrospective study of 168 patients (HBV, HCV, controls).
Collected serum biomarkers (APRI, FIB-4) and imaging biomarkers (Q-LSC, CEI, RV/TV) from MRI.
Applied SuStaIn to z-scored biomarkers to determine progression sequence.

Main Results:

Established a consistent biomarker conversion order: APRI, FIB-4, CEI, Q-LSC, RV/TV.
This sequence was consistent across HBV and HCV patients.
SuStaIn identified distinct stages of liver fibrosis progression.

Conclusions:

Abnormalities in serum biomarkers precede changes in hepatic gadoxetic acid uptake.
Liver lobe atrophy is a late-stage manifestation of fibrosis progression.
SuStaIn provides new insights into liver fibrosis progression in viral hepatitis.