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Updated: May 23, 2025

Mixed Reality Assisted Radical Endoscopic Thyroidectomy
Published on: January 31, 2025
Severe Amiodarone-Induced Thyrotoxicosis in 2 Patients Who Required Plasmapheresis Before Thyroidectomy
Morgane Ducarme1, Jessika Scaillet2, Mickaël De Cubber1
1Department of Endocrine Surgery, CH Epicura, Hornu 7301, Belgium.
Abstract:
Amiodarone is a class III antiarrhythmic medication known for its complex interplay with thyroid physiology. Its prolonged half-life can result in persistent effects on thyroid function even after discontinuation. Amiodarone-induced thyrotoxicosis (AIT) is a serious and challenging complication due to these lasting effects. We present the cases of 2 patients who developed AIT resistant to standard medical treatment. Both patients required plasmapheresis sessions to reduce circulating levels of tetraiodothyronine (T4) prior to undergoing total thyroidectomy. Plasmapheresis is an effective intervention that significantly decreases circulating thyroid hormone levels, thereby lowering surgical risks associated with severe cardiac complications linked to thyrotoxicosis.
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