Ultrasonography: an aid in molecular subtyping of breast carcinoma
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View abstract on PubMed
Summary
This summary is machine-generated.Ultrasonography can predict breast cancer molecular subtypes. Posterior acoustic shadowing is linked to progesterone receptor status and Luminal A subtype, while triple-negative subtypes show posterior acoustic enhancement and circumscribed margins.
Area Of Science
- Oncology
- Radiology
- Pathology
Background
- Molecular subtypes of breast cancer necessitate targeted therapies.
- Early breast cancer diagnosis improves survival rates.
- A cost-effective imaging tool is needed for timely detection and molecular profiling.
Purpose Of The Study
- To assess the predictive value of ultrasonographic features for estrogen receptor, progesterone receptor, HER2/neu expression, and molecular subtypes of breast cancer.
Main Methods
- A study of 51 invasive breast carcinoma cases using ultrasonography and tissue biopsy.
- Sonographic parameters assessed via BI-RADS imaging features.
- Molecular subtypes classified according to the St. Gallen International Expert Consensus Panel.
Main Results
- Posterior acoustic shadowing correlated with progesterone receptor status (OR 36.58, p<0.001) and Luminal A subtype (OR 3.85, p=0.02).
- Triple-negative subtypes showed higher prevalence with posterior acoustic enhancement (OR 29.42, p<0.001) and circumscribed margins (OR 5.12, p=0.03).
- Vascularity association with subtypes lacked statistical significance, though observed more in triple-negative and Luminal B HER2+ cases.
Conclusions
- Specific sonographic features predict hormone receptor status and molecular subtypes of breast cancer.
- Ultrasound can serve as a primary imaging tool for predicting molecular subtypes, especially in resource-limited settings lacking immunohistochemistry testing.
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