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Comprehensive bioinformatics analysis of hub genes in ischemic heart failure and atrial fibrillation

Meimei Zhou1, Youkang Xu2, Lili Zhang1

  • 1Department of Rehabilitation, Huadong Hospital, Fudan University, Shanghai, China.

Frontiers in Cardiovascular Medicine
|March 11, 2025
PubMed

Insights

This study identified 10 hub genes associated with both ischaemic heart failure (IHF) and atrial fibrillation (AF). These genes, primarily linked to extracellular matrix, offer potential biomarkers for joint diagnosis and treatment strategies.

Area of Science:

  • Cardiovascular Research
  • Genomics
  • Molecular Biology

Background:

  • Atrial fibrillation (AF) and heart failure (HF) frequently coexist and influence each other.
  • The specific association between AF and ischaemic heart failure (IHF) is not well-defined.
  • Understanding the shared mechanisms is crucial for developing new therapeutic targets.

Purpose of the Study:

  • To identify common genes and pathways involved in both IHF and AF.
  • To provide new insights for the joint diagnosis and treatment of these conditions.
  • To explore potential biomarkers for co-occurring IHF and AF.

Main Methods:

  • Acquired HF and AF gene expression datasets from the Gene Expression Omnibus (GEO) database.
  • Identified common differentially expressed genes (DEGs) and performed enrichment analyses (GO, KEGG).
  • Utilized protein-protein interaction networks, hub gene identification, and single-cell expression analysis for validation.

Main Results:

  • Identified 20 common DEGs between IHF and AF, with 10 identified as hub genes.
  • Hub genes (SFRP4, FMOD, HAPLN1, LTBP4, SVEP1, BCL6, ANPEP, CD38, ATRNL1, BEX1) are predominantly involved in extracellular matrix (ECM) processes.
  • Signaling pathways including Wnt and TGF-β1/Smads are implicated; high expression observed in monocytes.

Conclusions:

  • The 10 identified hub genes show potential as biomarkers for IHF and AF.
  • These biomarkers are significantly associated with ECM and metabolic pathways, suggesting targets for combined therapeutic strategies.
  • This research lays the groundwork for novel approaches to the joint management of IHF and AF.
Abstract

Keywords:
atrial fibrillationbiomarkerscommon differentially expressed genesheart failurehub genesischemic heart failure

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