Miller's Syndrome with Bleeding Nasal Polyp

Area of Science:

• Pediatrics
• Genetics
• Otolaryngology

Background:

• Millers syndrome is a rare autosomal recessive disorder.
• It is characterized by craniofacial and limb abnormalities, including malar hypoplasia, micrognathia, cleft lip/palate, and skeletal malformations.
• Airway restriction is a common complication.

Purpose of the Study:

• To report a rare case of Millers syndrome in a pediatric patient.
• To highlight an unusual presentation of bleeding nasal polyps in a child with Millers syndrome.
• To describe the histopathological findings of the nasal masses.

Main Methods:

• Clinical case presentation and review of literature.
• Surgical removal of nasal masses.
• Histopathological examination of the excised nasal tissue.

Main Results:

• A 6-year-old child diagnosed with Millers syndrome presented with complete nasal obstruction due to bilateral, highly vascularized nasal polyps.
• Histopathology confirmed the nasal masses as nasal polyps with significant vascularity and mucopolysaccharide material.
• The child exhibited typical features of Millers syndrome, including facial and limb anomalies.

Conclusions:

• This case underscores the importance of considering unusual presentations, such as nasal polyps, in patients with rare genetic syndromes like Millers syndrome.
• Early diagnosis and management of airway compromise are crucial in affected children.
• Nasal polyps in this context may represent a unique manifestation requiring prompt surgical and pathological evaluation.