Related Experiment Video
Updated: May 9, 2026

07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
14.3K
Lymphoepithelial Cyst in the Elderly Neck: A Diagnostic Conundrum
Garima Upreti1, Shivani Lashkari1, Siddhi Patil1
1Department of Otorhinolaryngology, All India Institute of Medical Sciences, Rajkot, Gujarat India.
Summary
A neck cyst in a chronic tobacco user was initially concerning for cancer but was diagnosed as a lymphoepithelial cyst. This case highlights the importance of thorough evaluation for accurate diagnosis and management of neck masses.
Area of Science:
- Head and Neck Surgery
- Pathology
- Diagnostic Imaging
Background:
- Lateral neck cysts can present diagnostic challenges, sometimes mimicking malignancy.
- Chronic tobacco use is a risk factor for various head and neck pathologies.
- The term "branchial cyst" is often misapplied to various neck cysts.
Purpose of the Study:
- To report a case of a lateral neck cyst initially suspected to be malignant.
- To emphasize the diagnostic difficulties and the importance of histopathology.
- To discuss the implications of misnomers like "branchial cyst" in clinical practice.
Main Methods:
- Clinical presentation of a 50-year-old male with a right lateral neck cyst.
- Inconclusive initial imaging and Fine Needle Aspiration Cytology (FNAC).
- Surgical excision and subsequent histopathological examination of the cyst.
Main Results:
- Histopathology confirmed the cyst as a lymphoepithelial cyst.
- Initial investigations raised suspicion for malignancy, which was ultimately ruled out.
- The patient's history included chronic tobacco chewing.
Conclusions:
- Lymphoepithelial cysts can present as lateral neck masses and may be misdiagnosed.
- Comprehensive evaluation, including histopathology, is crucial for accurate diagnosis of neck cysts.
- Clarifying terminology and understanding the differential diagnosis are essential for appropriate patient management.

