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Related Experiment Video

Updated: May 23, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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The Impact of Primary Tumor Volume on Survival of Patients with Non-Surgically Treated Advanced-Stage Hypopharyngeal

Sasa Jakovljevic1,2, Vladimir Djordjevic1,2, Nada Tomanovic1,3

  • 1Faculty of Medicine, University of Belgrade, Deligradska 9, Belgrade, 11000 Serbia.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|March 11, 2025
PubMed
Summary
This summary is machine-generated.

Tumor volume is a significant predictor of survival in advanced hypopharyngeal carcinoma. Larger tumor volumes correlate with poorer outcomes, suggesting its inclusion in treatment protocols.

Keywords:
Advanced hypopharyngeal cancerCancer prognosisNon-surgical treatmentSurvivalTumor volume

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Area of Science:

  • Oncology
  • Head and Neck Surgery

Background:

  • Hypopharyngeal carcinoma is a challenging cancer with advanced stages often presenting with poor prognoses.
  • Accurate prognostic markers are crucial for tailoring treatment strategies and improving patient outcomes.

Purpose of the Study:

  • To evaluate the prognostic significance of primary tumor volume in patients with stage III-IV hypopharyngeal carcinoma.
  • To determine if tumor volume can predict overall survival (OS) and progression-free survival (PFS).

Main Methods:

  • A retrospective study of 71 patients with stage III-IV hypopharyngeal carcinoma.
  • Tumor volume was calculated using the ellipsoid volume approximation method.
  • Receiver Operating Characteristic (ROC) curve analysis was employed to assess predictive accuracy.

Main Results:

  • Male patients and those with a history of alcohol consumption exhibited larger tumor volumes.
  • The median overall survival was 12 months, and median progression-free survival was 9 months.
  • An optimal cutoff of 14.69 cm³ for tumor volume demonstrated 61% sensitivity and 89% specificity in outcome prediction.

Conclusions:

  • Primary tumor volume is an independent prognostic factor for survival in advanced hypopharyngeal carcinoma.
  • Incorporating tumor volume measurement into clinical practice may aid in risk stratification and treatment planning.
  • Further research into integrating tumor volume into novel treatment protocols is warranted.