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Updated: May 23, 2025
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Ruthenium-Catalyzed Asymmetric trans-Selective Hydrogenation of 2,3-Disubstituted Quinoxaline Derivatives
Zeyu Li1,2, Wei Hao1,2, Yuping Tang1
1Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China.
Abstract:
The asymmetric trans-selective hydrogenation of arenes has long been a significant challenge. In this work, we were able to control the trans/cis selectivity in ruthenium-catalyzed asymmetric hydrogenation of 2,3-disubstituted quinoxalines by varying the catalyst counteranion. Using density functional theory calculations, we investigated the weak interactions─such as CH/π and hydrogen bonding─among the counteranion, the catalyst framework, and the substrate, elucidating the fundamental influence of counteranions on trans/cis selectivity in the asymmetric hydrogenation of quinoxalines.
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