Evaluation of the Sysmex CN-6000 Coagulation Analyzer for Routine and Specialized Coagulation Testing in a Central Laboratory
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Background:
The Sysmex CN-6000 is a fully automated high-throughput coagulation analyzer. The objective of this study was to evaluate the analytical performance of the analyzer for routine and special coagulation testing in a high-throughput central laboratory of a university hospital.
Methods:
The within- and between-day precision and accuracy of 29 coagulation parameters were evaluated on the Sysmex CN-6000 using commercially available quality control materials. Patient plasma samples were used to compare results of coagulation measurements between the Sysmex CN-6000 and the Atellica COAG 360, including plasma samples with visual interference. The sample throughputs of both analyzers were compared using plasma samples from healthy volunteers.
Results:
Within- and between-day coefficients of variation were acceptable for all assays tested on the Sysmex CN-6000. High correlation and good agreement were observed when comparing coagulation results from the Sysmex CN-6000 and the Atellica COAG 360. Samples with visual interference showed comparable coagulation results between the two analyzers, with slightly better detection by the Sysmex CN-6000. The sample throughput per hour for analysis of a panel of five coagulation parameters was higher with the Sysmex CN-6000 compared to the Atellica COAG 360 (247 vs. 193 tests).
Conclusions:
The Sysmex CN-6000 demonstrated excellent analytical performance for a large number of coagulation parameters and has a high throughput capacity, ideal for the needs of a central laboratory with a high volume of routine and specialized coagulation testing.
