Blood Oxidative Stress System in Wound Healing After Severe Burns Treated by Meek Micrografting

This study aimed to investigate the effects of total antioxidant capacity (T-AOC), superoxide dismu-tase (SOD), and malondialdehyde (MDA) in blood on the postoperative wound healing process of patients with severe burns treated by Meek micrografting.

In total, 154 patients with severe burns who underwent Meek micrografting treatment were selected as the observation group, and 80 healthy people were taken as the control group. General clinical data were collected, and serum T-AOC, SOD, and MDA were analyzed by biochemical analysis. The patients in the observation group were further divided into high T-AOC group (n = 72) and low T-AOC group (n = 82). Postoperative skin graft fusion time, wound healing time, skin graft survival rate, and treatment outcome were compared based on the follow-up results. The patients in the observation group were divided into the group with good wound healing (n = 82) and the group with poor wound healing (n = 72). The relationship between T-AOC, SOD, and MDA and the degree of wound healing was explored by logistic regression analysis and Spearman's correlation analysis, and ROC was plotted to see whether the three had a predictive value for the degree of wound healing after Meek micrografting in patients with severe burns.

Serum T-AOC and SOD levels of patients in the observation group were lower than those of the control group, while the MDA level was higher. The skin graft fusion time and wound healing time of patients in the high T-AOC group were shorter than those in the low T-AOC group, and the patients in the high T-AOC group possessed a higher skin graft survival rate and a better therapeutic effect. Elevated serum T-AOC and SOD levels were protective factors for wound healing, whereas elevated MDA level was a risk factor. T-AOC and SOD showed positive correlation with the degree of wound healing, while MDA showed negative correlation. T-AOC, SOD, and MDA levels had a value in predicting the degree of wound healing.

In the postoperative wound healing process of severe burn patients treated by Meek micrografting, the degree of wound healing is positively correlated with the levels of T-AOC and SOD and negatively correlated with the level of MDA, and all three have a certain value in predicting the degree of postoperative wound healing.