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A Case of Screening Macroprolactinemia Using Polyethylene Glycol Precipitation Method
Clinical Laboratory
|March 11, 2025
Summary
Macroprolactinemia can cause falsely elevated prolactin (PRL) levels, mimicking hyperprolactinemia. This case highlights how macroprolactin interference can be identified, preventing misdiagnosis and unnecessary treatments.
Area of Science:
- Endocrinology
- Clinical Chemistry
Background:
- Hyperprolactinemia involves elevated serum prolactin (PRL).
- Macroprolactinemia is characterized by high molecular weight PRL with low biological activity.
- Macroprolactin can cause falsely elevated PRL measurements.
