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Implantation and Monitoring by PET/CT of an Orthotopic Model of Human Pleural Mesothelioma in Athymic Mice
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Clinical Significance of Bone Metastases in Pleural Mesothelioma

Mitsutomi Miyake1, Kozo Kuribayashi1, Hiroshi Doi2

  • 1Department of Respiratory Medicine and Hematology, Hyogo Medical University, Nishinomiya, Japan.

Thoracic Cancer
|March 11, 2025
PubMed
Abstract

Insights

Bone metastasis (BoM) occurs in 11.5% of pleural mesothelioma (PM) patients, with non-epithelial histology being a risk factor. Patients with BoM face a poorer prognosis, highlighting the clinical significance of bone metastasis in PM.

Area of Science:

  • Oncology
  • Thoracic Surgery
  • Pathology

Background:

  • Bone metastasis (BoM) is a frequent complication in advanced cancers.
  • The incidence and clinical significance of BoM in pleural mesothelioma (PM) are not well-established.
  • Understanding BoM in PM is crucial for patient management and prognosis.

Purpose of the Study:

  • To determine the incidence of BoM in patients with pleural mesothelioma.
  • To identify risk factors associated with the development of BoM in PM.
  • To evaluate the prognostic impact of BoM on overall survival in PM patients.

Main Methods:

  • Retrospective analysis of 515 histologically confirmed PM patients (2011-2020).
  • Kaplan-Meier method for cumulative incidence calculation.
  • Multivariate logistic regression to identify risk factors for BoM.

Main Results:

  • BoM was diagnosed in 11.5% of PM patients, either at initial diagnosis or during progression.
  • Non-epithelial histology was identified as an independent risk factor for BoM (OR: 2.189).
  • Patients with BoM exhibited significantly worse overall survival (median 18.6 months vs. 21.7 months).

Conclusions:

  • BoM is less frequent in PM than in lung cancer, but associated with non-epithelial histology.
  • The presence of BoM portends a poor prognosis for pleural mesothelioma patients.
  • Further prospective studies are warranted to confirm these findings due to the retrospective nature of this study.
Keywords:
bone metastasiskeynote 483pleural mesotheliomaprognosisskeletal‐related events

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